Association of Clinical Research Professionals (ACRP) Certified Professional Practice Exam

What is the standard dosing recommendation for medicinal products in the pediatric population?

1. Per body surface area

2. Per unit age

3. In mg/kg body weight

4. As a fixed dose

The correct answer is: In mg/kg body weight

The standard dosing recommendation for medicinal products in the pediatric population is typically calculated in milligrams per kilogram of body weight (mg/kg body weight). This method is preferred because it allows for a more accurate and individualized approach to dosing based on the child's weight, which can vary significantly among children of the same age. Using weight-based dosing accounts for the differences in metabolism and drug clearance seen in children compared to adults, ensuring that each child receives a dose that is appropriate for their specific body size and physiological status. It also helps prevent underdosing or overdosing, which can have serious consequences in the pediatric population where safety is paramount. While other methods such as body surface area or age-based dosing have their applications, they may not be as universally applicable or easy to implement as weight-based dosing, especially considering the wide range of weight variations in children. Overall, dosing in mg/kg is a foundational principle in pediatric pharmacotherapy, designed to optimize efficacy and minimize risks.