Association of Clinical Research Professionals (ACRP) Certified Professional Practice Exam

Which age group is particularly marked by issues of non-compliance in clinical trials?

1. Children

2. Infants

3. Adolescents

4. Adults

The correct answer is: Adolescents

The age group particularly marked by issues of non-compliance in clinical trials is adolescents. This is primarily due to several psychological and social factors that influence their behavior during the trial process. Adolescents often exhibit a desire for independence and may struggle with authority, which can lead to a lack of adherence to study protocols. Additionally, issues related to impulsivity and peer influence can further complicate their commitment to following the guidelines set forth in trials. Moreover, this age group may experience challenges in understanding the importance of compliance, leading to a higher likelihood of missed doses, failure to attend follow-up visits, or misunderstandings about the study requirements. The development stage of adolescents can also make them less likely to prioritize health-related activities, which can hinder their participation in clinical trials. In contrast, compliance issues are typically not as pronounced in other age groups such as children or infants, where caregivers play a significant role in managing participation and adherence to protocols. Adults may also face compliance challenges, but generally have more life experience and understanding of the importance of following study guidelines compared to adolescents.